46. “Design, synthesis and characterization of novel N-heterocyclic-1-benzyl-1H-benzo[d]imidazole-2-amines as selective TRPC5 ion channel inhibitors for suppression of progressive kidney disease”, Sharma, S.*; Pablo, J. L.; Greka, A.; Hopkins, C. R.* Poster Presentation at the 2018 Midwest Regional Meeting of the American Chemical Society, Ames, IA. October 23rd, 2018. Poster ID: 3047283.
45. “Development of potent and selective Kir channel inhibitors as vector management strategy for controlling the primary vector of Zika virus, Aedes aegypti”, Hopkins, C. R.*; Aretz, C. D.; Moritzer, M. J.; Sanford, A. G.; Hogan, A. M.; Portillo, M. V.; Kramer, M.; Denton, J. S.; Trigueros, R. R.; Piermarini, P. M. Poster Presentation at the 2018 Military Health System Research Symposium: Kissimmee, FL. August 20-23rd, 2018. Paper ID: MHSRS-18-0373, Poster #: 396.
44. “Discovery, synthesis and characterization of a series of (1-alkyl-3-methyl-1H-pyrazolo-5-yl)-2-(5-aryl-2H-tetrazol-2-yl)acetamides as novel GIRK1/2 potassium channel activators”, Sharma, S.*; Kozek, K.; Abney, K. K.; Weaver, C. D.; Hopkins, C. R.*Abstracts of Papers, Poster Presentation at the 256thNational Meeting of the American Chemical Society: Boston, MA: Paper ID: MEDI 143. August 19th, 2018.
Poster selected for the Sci-Mix Poster Session. August 20th, 2018.
43. “Discovery and synthesis of a novel metabotropic glutamate receptor subtype 4 positive allosteric modulator with anti-parkinsonian efficacy in rodent models”, Bollinger, S. R.; Engers, D. W.; Panarese, J.; West, M.; Engers, J. L.; Loch, M. T.; Rodriguez, A. L.; Blobaum, A. L.; Jones, C. K.; Thompson, A. D.; Conn, P. J.; Lindsley, C. W.; Niswender, C. M.; Hopkins, C. R.* Poster Presentation at the 36thNational Medicinal Chemistry Symposium: Nashville, TN: MEDI: 93. April 30th, 2018.
42. “Utilizing Basic Science to Inspire Drug Discovery Identification of Novel Dopamine Receptor 4 Antagonists”, Jeffries, D. E.; Witt, J. O.; McCollum, A. L.; Temple, K. J.; Hurtado, M. A.; Huseman, E. D.; O’Reilly, M. C.; Plumley, H. C.; Blobaum, A. L.; Harp, J. M.; Lindsley, C. W.; Hopkins, C. R.* Poster Presentation at the 36thNational Medicinal Chemistry Symposium: Nashville, TN: MEDI: 78. April 30th, 2018.
41. "Synthesis, structure-activity relationship studies and biological evaluation of novel and selective 1H-pyrrolo[2,3-b]pyridine-2-carboxamides as related phosphodiesterase 4B (PDE4B0 inhibitors", Vadukoot, A. K.; Sharma, S.; Hopkins, C. R.*Abstracts of Papers, Poster Presentation at the 255th National Meeting of the American Chemical Society: New Orleans, LA: March 18-22, 2018: Paper ID: 2863006.
40. “Novel MrgX1 allosteric agonists as non-habit forming anti-chronic pain therapeutics”, Hopkins, C. R.*; Li, Z.; Tseng, P.-Y.; Tiwari, V.; Xu, Q.; He, S.-Q.; Wang, Y.; Zheng, Q.; Han, L.; Wu, Z.; Blobaum, A. L.; Cui, Y.; Tiwari, V.; Sun, S.; Cheng, Y.; Huang-Lionnet, J. H. Y.; Geng, Y.; Xiao, B.; Peng, J.; Raja, S. N.; Guan, Y.; Dong, X. Poster Presentation at the 2017 Military Health System Research Symposium: Kissimmee, FL. August 28th, 2017. Paper ID: MHSRS-17-1247, Poster #: 396.
39. “Discovery and characterization of 1H-pyrazol-5-yl-2-phenylacetamides as novel, non-urea containing GIRK1/2 potassium channel activators”, Sharma, S.; Wieting, J. M.; Vadukoot, A. K.; Abney, K. K.; Bridges, T. M.; Vo, B.; Anderson, A.; Wickman, K. D.; Weaver, C. D.; Hopkins, C. R.*Abstracts of Papers, Poster Presentation at the 254th National Meeting of the American Chemical Society: Washington, DC: Paper ID: MEDI 75. August 20th, 2017.
Poster selected for the Sci-Mix Poster Session. August 21st, 2017.
38. “Differential effects of dopamine receptor antagonism on methamphetamine self-administration in female rats”, Huynh, Y. W.*; Larsen, C. E.; Thompson, B. M.; Callen, M. P.; Barrett, S. T.; Hopkins, C. R.; Bevins, R. A.; Murray, J. E. Poster Presentation at the 65th Annual Nebraska Symposium on Motivation: Lincoln, NE. April 20-21st, 2017.
37. “ML418: The first selective, sub-micromolar pore blocker of Kir7.1 potassium channels”, Kurata, H.*; Swale, D. R.; Kharade, S. V.; Sheehan, J.; Raphemot, R.; Voigtritter, K. R.; Figueroa, E. E.; Meiler, J.; Blobaum, A. L.; Lindsley, C. W.; Hopkins, C. R.; Denton, J. S. Abstracts of Papers, Poster Presentation at the 253rd National Meeting of the American Chemical Society: San Francisco, CA: Paper ID: MEDI 245. April 2017.
36. “Metabotropic glutamate receptor 7 as a therapeutic target for MECP2-related disorders”, Niswender, C. M.*; Gogliotti, R. G.; Fisher, N. M.; Senter, R.; Gould, R. W.; Adams, J. J.; Stanley, B. J.; Walker, A. G.; Zamorano, R.; Blobaum, A. L.; Engers, D. W.; Hopkins, C. R.; Lindsley, C. W.; Jones, C. K.; Xiang, Z.; Conn, P. J. Abstracts of Papers, Poster presented at Society of Neuroscience 2016: San Diego, CA, November 2016.
35. “Metabotropic glutamate receptor 7 as a therapeutic target for MECP2-related disorders”, Fisher, N. M.; Gogliotti, R. G.; Senter, R.; Gould, R. G.; Walker, A. G.; Zamorano, R.; Adams, J. J.; Blobaum, A. L.; Engers, D. W.; Hopkins, C. R.; Lindsley, C. W.; Xiang, Z.; Jones, C. K.; Conn, P. J.; Niswender, C. M. Abstracts of Papers, Poster presented at the Rett Syndrome Symposium 2016: Eaglewood Resort, IL, June 2016.
34. “Small molecule ALK inhibitors with improved selectivity and pharmacokinetics inhibit heterotopic ossification without toxicity in a mouse model of fibrodysplasia ossificans progressiva”, Perrien, D. S.*; Hopkins, C. R.; Lindsley, C.; Frist, A.; Durai, H.; Fleming, N.; Booton, S. E.; Hong, C. C. Abstracts of Papers, Poster Presentation at the American Society for Bone and Mineral Research Annual Meeting: Atlanta, GA. September 2016.
33. “Kir4.1 (KCNJ10) inhibition with a newly developed antagonist induces diuresis in rats”, Kharade, S. V.*; Kurata, H.; Hopkins, C. R.; Denton, J. S. Abstracts of Papers, Poster Presentation at Experimental Biology 2016: Abstract: 1272.3. San Diego, CA. April 2016.
32. “Discovery and characterization of the choline transporter inhibitor: N-((3-isopropylisoxazol-5-yl)methyl)-4-chloro-3-((1-methylpiperidin-4-yl)oxy)benazmide, VU6001221”, Bertron, J.*; Tarr, C.; Hopkins, C. R.; Ennis, E.; Wright, J.; Locuson, C.; Blakely, R.; Lindsley, C. Abstracts of Papers, Poster Presentation at the 71st SWRM/67th SERMACS: Memphis, TN: Paper ID: 494. November 2015.
31. “mGlu7 is critical for hippocampal plasticity and is a potential therapeutic target for the treatment of Rett Syndrome”, Klar, R.*; Gogliotti, R. G.; Walker, A. G.; Zamorano, R.; Engers, D. W.; Ghose, D.; Grueter, B. A.; Hopkins, C. R.; Lindsley, C. W.; Xiang, Z.; Conn, P. J.; Niswender, C. M. Abstracts of Papers, Poster presented at Society of Neuroscience, 2015: Abstract ID: 120.14/A97. Chicago, IL, October 2015.
30. “Development of novel mGlu1 PAMs: Chemical tools to improve functionality of mutant receptor isoforms found in a schizophrenic population”, Garcia-Barrantes, P.*; Cho, H.; Brogan, J.; Niswender, C.; Hopkins, C.; Conn, J.; Lindsley, C. Abstracts of Papers, Poster Presentation at the 250th National Meeting of the American Chemical Society: Boston, MA: Paper ID: 78. August 2015.
29. “Development of novel and selective mGlu1 PAMs: chemical modulation to improve functionality of mutant receptor isoforms found in schizophrenics”, Garcia-Barrantes, P. M.; Cho, H. P.; Brogan, J. T.; Hopkins, C. R.; Niswender, C. M.; Morrison, R. D.; Daniels, J. D.; Conn, P. J.; Lindsley, C. W. Poster presentation at the 66th Southeast Regional Meeting of the American Chemical Society: Nashville, TN. Abstract: SERMACS-51. October 2014.
28. “Development of novel mGlu1 PAMs as tools to improve functionality of mutant receptor isoforms found in a schizophrenic population”, Garcia-Barrantes, P. M.; Cho, H. P.; Brogan, J. T.; Hopkins, C. R.; Niswender, C. M.; Morrison, R. D.; Daniels, J. S.; Conn, P. J.; Lindsley, C. W. Poster presentation at the 8th International Meeting on Metabotropic Glutamate Receptors, Sept. 28th – Oct. 3rd, 2014. Poster #18.
27. “Imaging the antiparkinsonian effects of the novel metabotropic glutamate receptor subtype 4 positive allosteric modulator ADX88178”, Byun, N.; Huang, A.; Baheza, R. A.; Barry, R. L.; Lindsley, C. W.; Hopkins, C. R.; Niswender, C.; Jones, C. K.; Gore, J. C.; Conn, P. J. Poster presentation at the 8th International Meeting on Metabotropic Glutamate Receptors, Sept. 28th – Oct. 3rd, 2014. Poster #77.
26. “Discovery and characterization of ML204, a novel inhibitor of the TRPC4 and TRPC5 ion channels that has been shown to protect the kidney filter”, Hopkins, C. R.*; Schaldecker, T.; Kim, S.; Tarabanis, C.; Tian, D.; Hakroush, S.; Castonguay, P.; Ahn, W.; Wallentin, H.; Heid, H.; Lindsley, C. W.; Salovich, J. M.; Riccio, A.; Buvall, L.; Weins, A.; Greka, A. Abstracts of Papers, Oral Presentation at the 248th National Meeting of the American Chemical Society: San Francisco, CA: Paper ID: 20. August 2014.
25. “Development of non-isatin M1 positive allosteric modulators”, Panarese, J. D.*; Rook, J. M.; Poslusney, M. S.; Melancon, B. J.; Bridges, T. M.; Cho, H. P.; Dickerson, J.; Hopkins, C.; Wood, M. R.; Xiang, Z.; Morrison, R.; Stauffer, S. R.; Daniels, J. S.; Niswender, C.; Jones, C. K.; Conn, P. J.; Lindsley, C. W. Abstracts of Papers, Poster Presentation at the 248th National Meeting of the American Chemical Society: San Francisco, CA: Paper ID: 130. August 2014.
24. “Development of a potent and ALK2 selective bone morphogenetic protein receptor (BMP) inhibitor”, Hopkins, C. R.*; Engers, D. W.; Frist, A. Y.; Lindsley, C. W.; Hong, C. H. Abstracts of Papers, Oral Presentation at the 246th National Meeting of the American Chemical Society: Indianapolis, IN: Paper ID: 219. September 2013.
23. “Discovery and structure-activity relationship of a novel choline transporter inhibitor (ML352)”, Engers, D. W.*; Ennis, E. A.; Ruggiero, A. M.; Blakely, R. D.; Hopkins, C. R.*; Lindsley, C. W. Abstracts of Papers, Poster presented at the 246th National Meeting of the American Chemical Society: Indianapolis, IN: Paper ID: 284. September 2013 (Selected for Sci-Mix).
22. “A screen with potential: high-throughput screening efforts to identify novel inhibitors and activators of the presynaptic choline transporter”, Ennis, E. A.*; Ruggiero, A. M.; Wright, J.; Hopkins, C. R.; Lindsley, C. A.; Blakely, R. D. Abstracts of Papers, Poster presented at Biomedical Transporters 2013: St. Moritz, Switzerland. August 2013.
21. “High-throughput screen for novel inhibitors and activators of the presynaptic choline transporter”, Ennis, E. A.*; Ruggiero, A. M.; Wright, J.; Hopkins, C. R.; Lindsley, C. W.; Blakely, R. D. Abstracts of Papers, Poster presented at Regulation of Neurotransmitters, Society of Neuroscience, 2012: New Orleans, LA: Abstract 740.15, October 2012.
20. “Effects of metabotropic glutamate receptor activation on neuroinflammation”, Dickerson, J. W.*; Nedelcovych, M. T.; Stauffer, S. R.; Hopkins, C. R.; Niswender, C. M.; Lindsley, C. W.; Jones, C. K.; Conn, P. J. Abstracts of Papers, Poster presented at Metabotropic Glutamate Receptors I, Society of Neuroscience, 2012: New Orleans, LA: Abstract 740.15, October 2012.
19. “Characterization of novel positive allosteric modulators of Group III metabotropic glutamate receptors utilizing in vitro studies”, Field, J. R.*; Melancon, B. J.; Zamorano, R.; Engers, D. W.; Salovich, J. M.; Cheung, Y. Y.; Days, E. L.; Lewis, L. M.; Xiang, Z.; Weaver, C. D.; Jones, C. K.; Wood, M. R.; Hopkins, C. R.; Lindsley, C. W.; Conn, P. J.; Niswender, C. M. Abstracts of Papers, Poster presented at G-Protein Coupled Receptors: Molecular Mechanisms and Novel Functional Insights”, Keystone Symposium 2012: Banff, Alberta, February 2012.
18. “Discovery of an inward rectifying potassium channel inhibitor with preference for Kir2.2, Kir3.X and Kir7.1”, Raphemot, R.*; Lonergan, D.; Nguyen, T. T.; Utley, T. J.; Rogliotti, R.; Hopkins, C. R.; Lewis, L. M.; Lindsley, C. W.; Weaver, C. D.; Denton, J. S. Abstract of Papers, Poster presented at Experimental Biology 2012: San Diego, CA.
17. “Co-administration of an mGlu4 positive allosteric modulator and the A2A antagonist preladenant improves efficacy in preclinical models of Parkinson’s disease”, Dickerson, J. W.*; Thompson, A. D.; Jones, C. K.; Niswender, C. M.; Hopkins, C. R.; Lindsley, C. W.; Conn, P. J. Abstracts of Papers, Poster presented at Nanosymposium: 638. Parkinson’s Disease: Neural Mechanisms, Society of Neuroscience, 2011: Washington, D. C.: Abstract 638.09, November 2011.
16. “mGlu4 receptor positive allosteric modulator development for the treatment of CNS disorders”, Niswender, C. M.*; Jones, C. K.; Hopkins, C. R.; Thompson, A. D.; Bubser, M.; Engers, D.; Gogliotti, R. D.; Blobaum, A. E.; Salovich, J. M.; Cheung, Y. Y.; Morrison, R. D.; Dawson, E. S.; Zamorano, R.; Brewer, K. A.; Daniels, J. S.; Lindsley, C. W.; Conn, P. J., Oral presentation at the 7th International Meeting on Metabotropic Glutamate Receptors, Oct. 2nd – 7th, 2011.
15. “Discovery and SAR Development of a Novel Series of N-4-(2,5-dioxopyrrolidin-1-yl)-phenylpicolinamides, including ML182, as Positive Allosteric Modulators of Metabotropic Glutamate Receptor 4: A Novel Approach for the Treatment of Parkinson’s Disease”, Engers, D. W.; Le, U. M.; Zhou, Y.; Thompson, A. D.; Jadhav, S.; Gogliotti, R. D.; Lindsley, S. R.; Bolinger, J. L.; Menon, U. N.; Zamorano, R.; Daniels, J. S.; Blobaum, A. L.; Jones, C. K.; Weaver, C. D.; Conn, P. J.; Lindsley, C. W.; Niswender, C. M.; Hopkins, C. R.*, Poster presentation at the 7th International Meeting on Metabotropic Glutamate Receptors, Oct. 2nd – 7th, 2011.
14. “Drug Metabolism and Disposition of a Novel N-4-(2,5-dioxopyrrolidin-1-yl)-phenylpicolinamide Series of Positive Allosteric Modulators of Metabotropic Glutamate Receptor 4: Identification of ML182 as an Orally Efficacious mGluR4-PAM”, Blobaum, A. L.; Morrison, R.; Jadhav, S.; Engers, D. W.; Lindsley, S. R.; Zhou, Y.; Gogliotti, R. D.; Jones, C. K.; Niswender, C. M.; Conn, P. J.; Lindsley, C. W.; Hopkins, C. R.*; Daniels, J. S., Poster presentation at the 7th International Meeting on Metabotropic Glutamate Receptors, Oct. 2nd – 7th, 2011.
13. “Shape-based virtual screens to identify novel group I and III mGlu receptor allosteric modulator chemotypes”, Dawson, E. S.*; Smith, J. A.; Niswender, C. M.; Hopkins, C. R.; Gogliotti, R.; Stauffer, S.; Lindsley, C. W.; Conn, P. J., Poster presentation at the 7th International Meeting on Metabotropic Glutamate Receptors, Oct. 2nd – 7th, 2011.
12. “The Discovery and Development of Positive Allosteric Modulators of mGlu4 for the Treatment of Parkinson’s Disease”, Hopkins, C. R.*, Oral presentation at the 23rd International Congress on Heterocyclic Chemistry: Presentation O55, Glasgow, Scotland, July 31st – August 4th, 2011.
11. ”mGluR4 Positive Allosteric Modulator Development for the Treatment of CNS Disorders”, Niswender, C. M.*; Hopkins, C. R.; Jones, C. K.; Engers, D.; Thompson, A. D.; Field, J. R.; Gogliotti, R. D.; Blobaum, A. E.; Jadhav, S.; Salovich, J. M.; Cheung, Y.-Y.; Morrison, R. D.; Mulder, M. J.; Bolinger, J.; Dawson, E. S.; Zamorano, R.; Vinson, P. N.; Bubser, M.; Brewer, K. A.; Daniels, J. S.; Lindsley, C. W.; Conn, P. J. Abstracts of Papers, Poster presented at Metabotropic Glutamate Receptors: Disease and Aging, Society of Neuroscience, 2010: San Diego, CA: Abstract 642.9/E33, November 2010.
10. ”VU0364770, a potent and systemically active positive allosteric modulator of mGluR4, produces robust efficacy in preclinical models of Parkinson’s Disease”, Thompson, A. D.*; Jones, C. K.; Bubser, M.; Niswender, C. M.; Hopkins, C. R.; Engers, D.; Jadhav, S.; Lindsley, C. W.; Conn, P. J. Abstracts of Papers, Poster presented at Metabotropic Glutamate Receptors: Disease and Aging, Society of Neuroscience, 2010: San Diego, CA: Abstract 642.10/E34, November 2010.
9. “Synthesis and SAR of piperazinyl and homopiperazinyl analogs as positive allosteric modulators of mGluR4”, Cheung, Y. Y.*; Hopkins, C. R.; Niswender, C.; Lindsley, C. W.; Conn, P. J. Abstracts of Papers, Poster presented at: 240th American Chemical Society National Meeting: Boston, MA: Abstract 368, August 2010.
8. “Discovery and SAR Development of a Series of N-(4-acetamido)- and 4-(2,5-dioxopyrrolidin-1-yl)phenylpicolinamides as Positive Allosteric Modulators of Metabotropic Glutamate Receptor 4: A Novel Approach for the Treatment of Parkinson’s Disease”, Engers, D. W.*, Le, U. M.; Zhou, Y.; Jones, C. K.; Thompson, A. D.; Jadhav, S.; Menon, U. N.; Zamorano, R.; Daniels, J. S.; Morrison, R.; Blobaum, A. L.; Weaver, C. D.; Conn, P. J.; Lindsley, C. W.; Niswender, C. M.; Hopkins, C. R.Abstract of Posters, Presented at: High Throughput Chemistry & Chemical Biology Gordon Conference, Les Diablerets, Switzerland, June 2010.
7. “Discovery and SAR Development of Positive Allosteric Modulators of Metabotropic Glutamate Receptor 4: A Novel Approach for the Treatment of Parkinson’s Disease”, Gogliotti, R. D.*; Hopkins, C. R.; Jones, C. K.; Thompson, A. D.; Engers, D.; Salovich, J. M.; Cheung, Y.-Y.; Williams, R.; Gentry P. R.; Zhou, Y.; Johnson, K.; Jadhav, S.; Menon, U. N.; Zamorano, R.; Lindsley, C. W.; Weaver, C. D.; Conn, P. J.; Niswender, C. M. Abstract of Posters, Poster presented at: French American Chemical Society: Obernai, France, June 2010.
6. “Targeted Discovery of a Small-Molecule Inhibitor of the GIRK Channel”, Lonergan, D.; Hopkins, C.; Gogliotti, R.; Lindsley, C.; Denton, J. Abstract of Papers, Poster presented at: Association of University Anesthesiologists: Denver, CO, April 2010.
5. “The development of positive allosteric modulators of mGluR4 for the treatment of Parkinson’s disease”, Niswender, C. M.*; Hopkins, C. R.; Jones, C. K.; Thompson, A. D.; Engers, D.; Williams, R.; Zhou, S.; Salovich, J.; Cheung, Y.-Y.; Gogliotti, R. D.; Gentry, P. R.; Johnson, K. A.; Jadhav, S.; Menon, U.; Zamorano, R.; Days, E. L.; Lindsley, C. W.; Weaver, C. D.; Conn, P. J. Abstracts of Papers, Poster presented at: XVIII WFN World Congress on Parkinson’s Disease and Related Disorders: Miami, FL: Abstract 756, December 2009.
4. “Recent progress in the development of positive allosteric modulators of mGluR4 for the treatment of Parkinson’s disease”, Niswender, C. M.*; Hopkins, C. R.; Jones, C. K.; Thompson, A. D.; Engers, D.; Williams, R.; Zhou, S.; Salovich, J.; Cheung, Y.-Y.; Gogliotti, R. D.; Gentry, P. R.; Johnson, K. A.; Jadhav, S.; Menon, U.; Zamorano, R.; Days, E. L.; Lindsley, C. W.; Weaver, C. D.; Conn, P. J. Abstracts of Papers, Poster presented at Parkinson’s Disease: Mechanisms of Action, Society for Neuroscience 2009: Chicago, IL: Abstract 828.27, October 2009.
3. “Synthesis of 6-substituted- and 6,7-disubstituted-5H-pyrrolo[2,3-b]pyrazines via palladium-catalyzed heteroannulation using conventional and microwave heating”, Hopkins, C. R. and Collar, N. Poster presented at the Heterocyclic Chemistry Gordon Conference, Salve Regina University, Newport, RI, July 2004.
2. “Studies toward the total synthesis of naphthyridinomycin/bioxalomycin related compounds: The stereoselective synthesis of the AB-ring system of tetrazomine”, Hopkins, C. R. and Wipf, P. Abstracts of Papers, 220th Meeting of the American Chemical Society, August 2000; American Chemical Society: Washington, DC; Abstract 535.
1. “Efficient synthesis of 1,4-dihdyro-2H-isoquinoline-3,5,8-triones via cyclobutene ring expansion”, Hopkins, C. R. and Wipf, P. Abstracts of Papers, 31st Central Region Meeting of the American Chemical Society, Columbus Section, June 1999; American Chemical Society: Washington, DC, 1999; Abstract 270.