15. Hopkins, C. R.; Hong, C. C.; Lindsley, C. W.; Engers, D. W. Fused heterocyclic compounds as selective BMP inhibitors. U. S. 9,738,636, 2017.
14. Conn, P. J.; Lindsley, C. W.; Hopkins, C. R.; Niswender, C. M.; Gogliotti, R. D.; Salovich, J. M.; Engers, D. W.; Cheung, Y.-Y. Heterocyclic sulfone mGluR4 allosteric potentiators, compositions, and methods of treating neurological dysfunction. U. S. 9.192,603, 2015.
13. Conn, P. J.; Lindsley, C. W.; Hopkins, C. R.; Niswender, C. M.; Gogliotti, R. D. mGluR4 allosteric potentiators, compositions, and methods of treating neurological dysfunction. U. S. 9,180,192, 2015.
12. Conn, P. J.; Lindsley, C. W.; Hopkins, C. R.; Niswender, C. M.; Gogliotti, R. D.; Salovich, J. M.; Engers, D. W.; Cheung, Y.-Y. Pyrazolopyridine, pyrazolopyrazine, pyrazolopyrimidine, pyrazolothiophene and pyrazolothiazole compounds as mGluR4 allosteric potentiators, compositions, and methods of treating neurological dysfunction. U. S. 9,163,015, 2015.
11. Conn, P. J.; Lindsley, C. W.; Hopkins, C. R.; Niswender, C. M.; Gogliotti, R. D.; Salovich, J. M.; Engers, D. W.; Cheung, Y.-Y. Pyrazolopyridine, pyrazolopyrazine, pyrazolopyrimidine, pyrazolothiophene and pyrazolothiazole compounds as mGluR4 allosteric potentiators, compositions, and methods of treating neurological dysfunction. U. S. 9,108,963, 2015.
10. Lindsley, C. W.; Conn, P. J.; Wood, M. R.; Hopkins, C. R.; Melancon, B. J.; Poslusney, M. S. Substituted benzylspiroindolen-2-one analogs as positive allosteric modulators of the muscarinic receptor M1. U. S. 9,073,935, 2015.
9. Conn, P. J.; Lindsley, C. W.; Wood, M. R.; Hopkins, C. R.; Salovich, J. M.; Melancon, B. J. Substituted 1H-pyrazolo[3’,4’,4,5]thieno[2,3-b]pyridine-3-amine analogs as positive allosteric modulators of the muscarinic acetylcholine receptor M4. U. S. 9,056,876, 2015.
8. Hong, C. C.; Hopkins, C. R.; Hatzopoulos, A. K.; Lindsley, C. W.; Hao, J. Compounds and methods useful for directing stem cell differentiation. U. S. 9,040,694, 2015.
7. Conn, P. J.; Lindsley, C. W.; Hopkins, C. R.; Niswender, C. M.; Engers, D. W. Benzisoxazoles and azabenzisoxazoles as mGluR4 allosteric potentiators, compositions, and methods of treating neurological dysfunction. U.S. 8,916,584, 2014.
6. Conn, P. J.; Lindsley, C. W.; Hopkins, C. R.; Weaver, C. D.; Niswender, C. M.; Cheung, Y.-Y. Aryl and heteroaryl sulfones as mGluR4 allosteric potentiators, compositions, and methods of treating neurological dysfunction. U.S. 8,912,336, 2014.
5. Hong, C. C.; Hopkins, C. R.; Hatzopoulos, A. K.; Lindsley, C.; Hao, J. Compounds and methods useful for directing stem cell differentiation. U.S. 8,822,684, 2014.
4. Conn, P. J.; Lindsley, C. W.; Hopkins, C. R.; Weaver, C. D.; Niswender, C. M.; Engers, D. W.; Cheung, Y.-Y.; Gentry, P. R.; Salovich, J. M.; Gogliotti, R. D. mGluR4 Allosteric Potentiators, Compositions, and Methods of Treating Neurological Dysfunction. U.S. 8,779,157, 2014.
3. Conn, P. J.; Lindsley, C. W.; Hopkins, C. R.; Weaver, C. D.; Niswender, C. W.; Engers, D. W. Substituted dioxopiperidines and dioxopyrrolidines as mGluR4 allosteric potentiators, compositions, and methods of treating neurological dysfunction, U.S. 8,759,377, 2014.
2. Conn, P. J.; Lindsley, C. W.; Hopkins, C. R.; Weaver, C. D.; Niswender, C. M.; Gogliotti, R. D.; Engers, D. W. Substituted 1,1,3,3-tetraoxidobenzo[d][1,3,2]dithiazoles as mGluR4 allosteric potentiators, compositions, and methods of treating neurological dysfunction, U.S. 8,658,650, 2014.
1. Majid, T.; Hopkins, C. R.; Pedgrift, B. L.; Collar, N.; Wirtz-Brugger, F.; Merrill, J. Preparation of pyrazoloisoquinolines as NFkB-inducing kinase (NIK) inhibitors. U.S. 7,132,428, 2005.
Patent Applications
26. Hopkins, C. R.; Hong, C. C.; Lindsley, C. W.; Engers, D. W. Inhibition of bone morphogenetic protein (BMP) signaling using un(substituted) imidazo[1,2-a]pyridines and methods of use thereof in the treatment of cancer and other diseases, WO2018/053126, 2018, 140 pp.
25. Conn, P. J.; Lindsley, C. W.; Hopkins, C. R.; Felts, A.; Bender, A. M. Isoquinoline amide and isoquinoline amide-substituted compounds as mGluR4 allosteric potentiators, compositions, and methods of treating neurological dysfunction, U. S. Pat. Appl. Publ. US2018/0057491, 2018, 43 pp.
24. Hopkins, C. R.; Hong, C. C.; Lindsley, C. W.; Engers, D. W. Fused heterocyclic compounds as selective BMP inhibitors, U. S. Pat. Appl. Publ. US2016/0068525, 2016, 93 pp.
23. Conn, J. P.; Hopkins, C. R.; Lindsley, C. W.; Niswender, C. M.; Engers, D. W.; Panarese, J.; Bollinger, S.; Engers, J.; Bronson, J.; Wu, Y.-J.; Guernon, J. Indazole and azaindazole substituted compounds as mGluR4 allosteric potentiators, compositions, and methods of treating neurological dysfunction, PCT Int. Appl. WO2016/123629, 2016, 180 pp.
22. Conn, J. P.; Hopkins, C. R.; Lindsley, C. W.; Niswender, C. M.; Emmitte, K.; Bronson, J.; Wu, Y.-J.; Panarese, J.; Engers, D. W.; Engers, J. Isoquinoline and naphthalene-substituted compounds as mGluR4 allosteric potentiators, compounds, and methods of treating neurological dysfunction, PCT Int. Appl. WO2016/123627, 2016, 136 pp.
21. Conn, P. J.; Hopkins, C. R.; Lindsley, C. W.; Niswender, C. M.; Engers, D. W.; Bollinger, S. Benzothiazole and benzisothiazole-substituted compounds as mGluR4 allosteric potentiators, compositions, and methods of treating neurological dysfunction, PCT Int. Appl. WO2016/115272, 2016, 99 pp.
20. Conn, P. J.; Hopkins, C. R.; Lindsley, C. W.; Niswender, C. M.; Engers, D. W.; Panarese, J.; Bollinger, S.; Engers, J. Benzoisoxazole-substituted compounds as mGluR4 allosteric potentiators, compositions, and methods of treating neurological dysfunction, PCT Int. Appl. WO2016/115282, 2016, 157 pp.
19. Hopkins, C. R.; Hong, C. C.; Lindsley, C. W.; Engers, D. W. Fused heterocyclic compounds as selective BMP inhibitors, PCT Int. Appl. 2014/051698, 2014, 134 pp.
18. Lindsley, C. W.; Conn, P. J.; Wood, M. R.; Hopkins, C. R.; Melancon, B. J.; Poslusney, M. S. Preparation of substituted benzylspiroindolin-2-one derivatives as positive allosteric modulators of mAChR M1 receptor, PCT Int. Appl. 2013/071201, 2013, 318 pp.
17. Lindsley, C. W.; Conn, P. J.; Wood, M. R.; Hopkins. C. R.; Melancon, B. J.; Poslusney, M. S.; Engers, D. W. Substituted 2-(4-heterocyclylbenzyl)isoindolin-1-one analogs as positive allosteric modulators of the muscarinic acetylcholine receptor M1, PCT Int. Appl. 2013/063549, 2013, 320 pp.
16. Conn, P. J.; Lindsley, C. W.; Wood, M. R.; Hopkins, C. R.; Salovich, J. M.; Melancon, B. J. Preparation of substituted 1H-pyrazolo[3',4',4,5]thieno[2,3-b]pyridin-3-amine analogs as positive allosteric modulators of the muscarinic acetylcholine receptor M4, PCT Int. Appl. 2013/040534, 2013, 383 pp.
15. Conn, P. J.; Lindsley, C. W.; Hopkins, C. R.; Chauder, B. A.; Gogliotti, R. D.; Wood, M. R. Preparation of substituted 1H-pyrrole[3,2-c]quinolin-4(5H)-one analogs as positive allosteric modulators of the muscarinic acetylcholine receptor M4, PCT Int. Appl. 2012/154731, 2012; 184 pp.
14. Conn, P. J.; Lindsley, C. W.; Hopkins, C. R.; Weaver, C. D.; Gogliotti, R. D.; Engers, D. W. Substituted Substituted 1,1,3,3-tetraoxidobenzo[d][1,3,2]dithiazoles as mGluR4 allosteric potentiators, compositions, and methods of treating neurological dysfunction. U. S. Patent Appl. US 2011/0319429, 2011; 67 pp.
13. Conn, P. J.; Lindsley, C. W.; Hopkins, C. R.; Weaver, C. D. Niswender, C. M.; Gogliotti, R. D.; Cheung, Y.-Y.; Salovich, J. M.; Engers, D. W. Heterocyclic sulfone mGluR4 allosteric potentiators, compositions, and methods of treating neurological dysfunction, PCT Int. Appl. 2011/143466, 2011; 102 pp.
12. Conn, P. J.; Lindsley, C. W.; Hopkins, C. R.; Weaver, C. D. Niswender, C. M.; Engers, D. W. Benzisoxazoles and azabenzisoxazoles as mGluR4 allosteric potentiators, compositions, and methods of treating neurological dysfunction, PCT Int. Appl. 2011/100614, 2011; 112 pp.
11. Conn, P. J.; Lindsley, C. W.; Hopkins, C. R.; Niswender, C. M.; Gogliotti, R. D.; Salovich, J. M.; Engers, D. W.; Cheung, Y.-Y. Pyrazolopyridine, pyrazolopyrazine, pyrazolopyrimidine, pyrazolothiophene and pyrazolothiazole compounds as mGluR4 allosteric potentiators, compounds, and methods of treating neurological dysfunction, PCT Int. Appl. 2011/100607, 2011; 123 pp.
10. Conn, P. J.; Lindsley, C. W.; Hopkins, C. R.; Weaver, C. D.; Niswender, C. M.; Engers, D. W. Substituted dioxopiperidines and dioxopyrrolidines as mGluR4 allosteric potentiators, compositions, and methods of treating neurological dysfunction, US Pat. Appl. Publ. 2011/0124663, 2011; 48 pp.
9. Conn, P. J.; Lindsley, C. W.; Hopkins, C. R.; Weaver, C. D.; Niswender, C. M.; Cheung, Y.-Y. Aryl and Heteroaryl Sulfones as mGluR4 Allosteric Potentiators, Compositions, and Methods of Treating Neurological Dysfunction PCT Int. Appl. 2011/057208, 2011; 106 pp.
8. Conn, P. J.; Lindsley, C. W.; Hopkins, C. R.; Niswender, C. M.; Gogliotti, R. D.; Salovich, J. M. mGluR4 Allosteric Potentiators, Compositions, and Methods of Treating Neurological Dysfunction PCT Int. Appl. 2011/050316, 2011; 136 pp.
7. Conn, P. J.; Lindsley, C. W.; Hopkins, C. R.; Niswender, C. M.; Gogliotti, R. D. mGluR4 Allosteric Potentiators, Compositions, and Methods of Treating Neurological Dysfunction PCT Int. Appl. 2011/050305, 2011; 136 pp.
6. Conn, P. J.; Lindsley, C. W.; Hopkins, C. R.; Weaver, C. D.; Niswender, C. M.; Engers, D. W.; Cheung, Y.-Y.; Gentry, P. R.; Salovich, J. M.; Gogliotti, R. D. mGluR4 Allosteric Potentiators, Compositions, and Methods of Treating Neurological Dysfunction. PCT Int. Appl. 2011/029104, 2011; 173 pp.
5. Conn, P. J.; Lindsley, C. W.; Hopkins, C. R.; Weaver, C. D.; Niswender, C. M.; Cheung, Y.-Y. Substituted benzimidazolesulfonamides and substituted indolesulfonamides as mGluR4 potentiators. PCT Int. Appl. 2011/011722, 2011; 131 pp.
4. Conn, P. J.; Lindsley, C. W.; Hopkins, C. R.; Weaver, C. D.; Niswender, C. M.; Gogliotti, R. D.; Engers, D. W. Substituted 1,1,3,3-tetraoxidobenzo[d][1,3,2]dithiazoles as mGluR4 allosteric potentiators, compositions, and methods of treating neurological dysfunction. PCT Int. Appl. WO2010/088406, 2010; 162 pp.
3. Hong, C. C.; Hopkins, C. R.; Hatzopoulos, A. K.; Lindsley, C. W.; Hao, J. Compounds and Methods Useful for Directing Stem Cell Differentiation. US Pat. Appl. No. 12/537,037, 2009; 65 pp.
2. Majid, T. N.; Hopkins, C. R.; Pedgrift, B. L.; Collar, N.; Wirtz-Brugger, F.; Merrill, J. Pyrazoloisoquinoline derivatives as kinase inhibitors, and their preparation, pharmaceutical compositions, and use in the treatment of diseases involving increased NIK activity. PCT Int. Appl. WO2005/012301, 2005; 94 pp.
1. Hopkins, C. R. and Collar, N. Synthetic Process of Making Substituted Azaindoles, Serial No. 60/550,440; U. S. Patent Pending.