Welcome to the Hopkins Laboratory of synthetic medicinal chemistry. Our group has recently moved to the University of Nebraska Medical Center in the Department of Pharmaceutical Sciences. Our primary research interests are related to the design, synthesis and optimization of biologically active small molecules as in vivo probes, drug discovery lead compounds and preclinical candidates. Work here at UNMC will focus on developing novel chemical probes as: Claudin inhibitors for treatment of colorectal cancer, G protein-coupled inwardly-rectifying potassium channel (GIRK) activators as novel anxiolytics and pain treatments, and novel Dopamine receptor 4 antagonists for L-DOPA-induced dyskinesia and addiction.
Research News:
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NEWS
December 15th, 2023 Kirsten graduates from UNMC with her doctorate. Congrats to Dr. Tolentino! May 11th, 2023 Congratulations to Kirsten for a successful dissertation defense. Dr. Tolentino is the 2nd PhD from the Hopkins Lab. August 1st, 2023 The UNMC Center for Drug Design and Innovation has been officially approved! Dr. Hopkins is the inaugural Director! December 2022 The group welcomes Fahad Rahman as a 1st year graduate student August 2022 The group welcomes Dr. Saeedeh Saeedi as a 1st year graduate student. April 1st, 2022 It's not a joke! The Hopkins lab received a new R01 from the NINDS to study GIRK1/2 activators in pain models. March 2022 The group welcomes Thomas Webster as a 1st year graduate student. November 3rd, 2021 Congratulations to Swagat for successfully defending his dissertation and becoming Dr. Sharma!! August 2021 The group welcomes Sumaiya Nahid as a 1st year graduate student July 1st, 2021 Dr. Hopkins was promoted to Professor. The Hopkins Lab received a new R01 from the NINDS to study D4 antagonists in Parkinson's disease. February 15th, 2021 The Hopkins lab received a new R01 (with co-PI Prof. Punita Dhawan) from the NCI to study Claudin-1 inhibitors and colorectal cancer. November 2019 Dr. Hopkins was elected as an Alternate Academic Councilor for the American Chemical Society's Division of Medicinal Chemistry (2020-2022). October 17th, 2019 Dr. Hopkins receives the 2019 Most Promising Invention Award from UneMed. October 2nd, 2019 Dr. Hopkins is highlighted on KTEV's report on the Midwest Drug Development conference. August 21st, 2019 Dr. Hopkins organized and presided over the "Emerging Targets for Drug Abuse Therapy" at the 258th National Meeting of the American Chemical Society in San Diego February 2nd, 2018 Dr. Hopkins is a 2017 UNMC Distinguished Scientist December 21st, 2017 Dr. Hopkins' (and collaborators) work on TRPC5 channels and kidney disease is highlighted in the Omaha-World Herald. March 28th, 2017 The Hopkins Lab is on Twitter! March 28th, 2017 The Hopkins laboratory is featured on the front page of the Omaha World Herald. January 27th, 2017 Dr. Hopkins' work on novel Kir inhibitors as novel mosquitocides is highlighted by the NIH, Scientific American and others. December 2016 A novel dopamine D4 antagonist developed in the Hopkins Lab shows significant efficacy in an animal model of Parkinson's disease. June 27th 2016 The Hopkins Laboratory has started at UNMC PEOPLE September The lab welcomes two more students. First year rotation student Kirsten Antonio-Tolentino and HS Alliance student Esmeralda Rodriquez. July/August 2018 The lab welcomes two more IGPBS rotation students. Upendra Chalise and Kathleen Hecker May 29th, 2018 The lab welcomes two new students. Wacey Gallegos will be spending the summer with us as an INBRE Scholar. Natalie Mostek will be starting her internship from UNO with us. March 22nd, 2018 The Lab welcomes Dr. Christopher Aretz as a post-doctoral researcher November 14th, 2017 The Lab welcomes rotation student Austin Sanford as part of the IGPBS program. September 18th, 2017 The Lab welcomes rotation student Jane Morwitzer as part of the IGPBS program. September 5th, 2017 We welcome two High School Alliance students Alicia Hogan and Madelene Portillo from Omaha South High School for the fall. June 2nd, 2017 We welcome summer rotation student Andrew Neville as part of the IGPBS program. February 6th, 2017 We welcome Dr. John Saathoff as a post-doctoral researcher. August 30th, 2016 We welcome Dr. Anish K. Vadukoot as a post-doctoral researcher. August 11th, 2016 We welcome Pharmaceutical Sciences graduate student, Sharma Shagat to the lab! |